Swissvale is named after the Swisshelm family. John Swisshelm (1752–1838), who owned a farm where the town is located. John Swisshelm served under General George Washington in the Revolutionary War, and camped at Valley Forge. Swisshelm married Mary Elizabeth Miller, and they had many children. Their son, James Swisshelm, married Jane Grey Cannon, noted abolitionist and political activist, Jane Swisshelm named the town Swissvale as the town overlooked the Monongahela River Valley. The Pittsburgh neighborhood of Swisshelm Park, adjacent to Swissvale, is named after John Swisshelm.

Since 1874, the Allegheny Car & Transportation Shops had provided well-paying jobs to local citizens and were later purchased by George Westinghouse, the President of Westinghouse Air Brake Company, who formed the Union Switch & Signal company and maintained that facility in Swissvale.

Swissvale has six land borders, including Edgewood to the north, Braddock Hills to the east, North Braddock to the southeast, Rankin to the south, and the Pittsburgh neighborhoods of Regent Square and Swisshelm Park to the west. (The area known as Regent Square also encompasses portions of Pittsburgh, Wilkinsburg, Edgewood, and Swissvale.) Directly across the Monongahela River to the southwest is the borough of Munhall.

The population was 8,624 at the 2020 census.

A Cultural Survey of Swissvale, PA    Fall, 1992 by Michelle Fanzo