The Pine Grove United Presbyterian Church was organized in 1879; the first service being held in on the second floor of the Pine Grove School House on Center Street on April 6, 1879.  Over the next several months, services were held in various places:  an additional service at the school house, along Wolf Creek near where the Pine Grove Hotel now stands, and at an unoccupied Presbyterian Meeting House near the corner of Broad and Poplar Streets.  It was in the meeting house that the Pine Grove United Presbyterian Church was formally instituted on September 10, 1879.

Charter members of the church included:  Mr. and Mrs. D. C. Craig, Mr. and Mrs. J. A. Craig, Mattie Cummings, Mr. and Mrs. Samuel Cummings, Mr. and Mrs. W. M. Frew, Margaret M. Kelly, Margaret Mc Bride, Eliza McFate, Mr. and Mrs. A. B. McKay, Mr. and Mrs. W. J. McKay, Mr. and Mrs. Joseph McKee, Jennie Miller, Mr. and Mrs. G. W. White, Mr. and Mrs. J. N. White, Marie White, Narcissa White, and Susanna White.

In 1883, when Pine Grove was renamed Grove City, the church officially became the First United Presbyterian Church of Grove City.

The congregation moved into a frame building off of Main Street, costing $5,000, in May 1883.  This church was destroyed by fire in 1892.

A new red brick church was built in 1893 on the site of the old church.  This building was outgrown in the early 1900s.

The present church building, built across Main Street from the old church, was dedicated on July 12, 1909.

In 1958, the name of the church was changed to the East Main United Presbyterian Church.